Initial forays into the large-scale genetic and chemical characterization cancer cell lines As The Cancer Genome Anatomy (TCGA) project embarked on the efforts to define the genetic basis of human cancers it was clear that a similar effort would be required to characterize the cancer cell lines. Hence, the profound sensitivity of cancers bearing activating EGFR mutations was initially missed, at least in part due to the lack of large-scale, robust well-defined cancer cell line models. This starkly contrasts with the number of patients (n=952) treated on the initial phase III trials of EGFR inhibitors. For example, at the time of the discovery of EGFR mutations in lung cancer, EGFR inhibitors had been developed using a single cell line, A549 as the EGFR-inhibitor sensitive model. Prior to the CCLE, cell line investigations were limited to a few commonly used cell lines or at most the 60 cell lines of the NCI60 panel. Motivations for the Cancer Cell Line Encyclopedia (CCLE)Ĭancer cell lines are the most commonly used models for studying cancer biology, validating cancer targets and for defining drug efficacy.
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